Fresh analysis indicates that patients who come off popular slimming jabs like Mounjaro or Wegovy tend to recover lost weight much more quickly than those who halt conventional lifestyle programs.
Findings released in a prominent medical journal points out that while overweight individuals can lose about a fifth of their total mass while undergoing treatment, the weight returns at an estimated rate of 0.8 kg per month after stopping.
"People using such medications should be cognizant of the risk of rapid rebound weight gain when the medication concludes," warns expert Dr. Susan Jebb.
That rate of regain implies a reversion to starting weight within about a year and a half.
Analyzing Approaches
The research, which examined dozens of studies involving over 9,000 of participants, contrasted the outcomes of these new drugs with other pills.
Scientists emphasize that individuals who lose weight through diet and exercise generally see a more gradual weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Rebound
Nutrition scientists propose the mode of action of the injections accounts for the amplified regain.
These medications imitate a natural hormone called glucagon-like peptide-1, which helps regulate appetite.
"Long-term administration of the hormone levels far above than normal could lead to the system to generate a reduced amount of its endogenous hormone, and could lessen responsiveness to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication leads to hunger is unsuppressed, making binge eating a significant risk."
An Ongoing Issue?
The NHS suggest the jabs for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Professionals contend that, considering the likelihood of weight regain, the treatment might need to be ongoing.
This perspective is supported by pharmaceutical companies, who note that the results "underscore the long-term nature of excess weight," similar to managing diseases like hypertension.
User Testimonies
Users who have stopped the medication report a sudden resurgence of hunger.
"It was like something activating and you become ravenous," recalled an individual.
This challenge is compounded if users have not adopted lasting dietary or behavioural modifications during treatment.
Significant Use
Figures show that millions of adults in the UK have tried these injections in the last 12 months, with interest continuing to grow.
- Adoption is more common among women compared to males.
- The 40s and 50s demographic shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than public health services.
In conclusion, researchers stress that while the jabs are potent tools for shedding pounds, they are not a magic solution and maintained weight loss hinges on ongoing behavioural changes.
